| Date | Opponent | Location | Time/Result | Record (Conf) | TV/Radio |
|---|---|---|---|---|---|
| September 5, 2010 | SMU | Lubbock, Texas | W 35-27 | 1-0 (0-0) | ESPN |
| September 11, 2010 | New Mexico | Albuquerque, New Mexico | W 52-17 | 2-0 (0-0) | The MTN |
| September 18, 2010 | Texas | Lubbock, Texas | L 24-14 | 2-1 (0-1) | ABC/ESPN |
| October 2, 2010 | Iowa State | Ames, Iowa | L 52-38 | 2-2 (0-2) | FCS |
| October 9, 2010 | Baylor | Dallas, Texas | W 45-38 | 3-2 (1-2) | FSN |
| October 16, 2010 | Oklahoma State | Lubbock, Texas | L 34-17 | 3-3 (1-3) | FCS |
| October 23, 2010 | Colorado | Boulder, Colorado | W 27-247 | 4-3 (2-3) | No TV |
| October 30, 2010 | Texas A&M | College Station, Texas | 2:30 PM | 0-0 (0-0) | No TV |
| November 6, 2010 | Missouri | Lubbock, Texas | 7:00 PM | 0-0 (0-0) | ABC |
| November 13, 2010 | Oklahoma | Norman, Oklahoma | TBA | 0-0 (0-0) | TBA |
| November 20, 2010 | Weber State | Lubbock, Texas | 2:00 PM | 0-0 (0-0) | TBA |
| November 27, 2010 | Houston | Lubbock, Texas | 7:00 PM | 0-0 (0-0) | TBA |
| Place Table Description/Information here. | |||||